Neuronal control of energy homeostasis
نویسندگان
چکیده
منابع مشابه
Role of Neuronal Glucosensing in the Regulation of Energy Homeostasis
Glucosensing is a property of specialized neurons in the brain that regulate their membrane potential and firing rate as a function of ambient glucose levels. These neurons have several similarities to and -cells in the pancreas, which are also responsive to ambient glucose levels. Many use glucokinase as a rate-limiting step in the production of ATP and its effects on membrane potential and io...
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Neuronal activity, astrocytic responses to this activity, and energy homeostasis are linked together during baseline, conscious conditions, and short-term rapid activation (as occurs with sensory or motor function). Nervous system energy homeostasis also varies during long-term physiological conditions (i.e., development and aging) and with adaptation to pathological conditions, such as ischemi...
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Recently, we established that recurrent activity evokes network sodium oscillations in neurons and astrocytes in hippocampal tissue slices. Interestingly, metabolic integrity of astrocytes was essential for the neurons' capacity to maintain low sodium and to recover from sodium loads, indicating an intimate metabolic coupling between the 2 cell types. Here, we studied if lactate can support neu...
متن کاملNeuronal SH2B1 is essential for controlling energy and glucose homeostasis.
SH2B1 (previously named SH2-B), a cytoplasmic adaptor protein, binds via its Src homology 2 (SH2) domain to a variety of protein tyrosine kinases, including JAK2 and the insulin receptor. SH2B1-deficient mice are obese and diabetic. Here we demonstrated that multiple isoforms of SH2B1 (alpha, beta, gamma, and/or delta) were expressed in numerous tissues, including the brain, hypothalamus, liver...
متن کاملHomeostasis in Neuronal Cells
in t ime and space in response to a variety of stimuli, and act as a pluripotent signal for many neuronal functions. Activation of cells is associated with C a 2 + influx from the extracellular space through voltage-dependent and/or receptor-operated C a 2 + channels localized on the plasma membrane, and/or by release of Ca + from intracellular stores to reach Ca" + concentrations of up to micr...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2007
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2007.11.063